منابع مشابه
Genetically susceptible subgroups.
In establishing "safe" standards for all with respect to environmental carcinogenesis, one must consider the heterogeneity of man. Although cancer is considered primarily an environmental disease, there is a wide range of genetic-environmental interaction which ultimately influences the development of malignant disease. Considerations of subgroups susceptible to environmental carcinogenesis req...
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3 " Det finns vissa saker som är absoluta, till exempel havsströmmar och årstider och att solen går upp om mornarna. Och att fyrarna brinner. " Tove Jansson " Pappan och havet " 4
متن کاملThe obesity epidemic: metabolic imprinting on genetically susceptible neural circuits.
The apparent obesity epidemic in the industrialized world is not explained completely by increased food intake or decreased energy expenditure. Once obesity develops in genetically predisposed individuals, their obese body weight is avidly defended against chronic caloric restriction. In animals genetically predisposed toward obesity, there are multiple abnormalities of neural function that pri...
متن کاملKininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats.
Genetically susceptible Lewis rats injected in the intestinal wall with peptidoglycan-polysaccharide (PG-APS) polymers develop chronic granulomatous enterocolitis concomitant with activation of the kallikrein-kinin system. To elucidate the role of high-molecular-weight kininogen (HK) in chronic enterocolitis, we back crossed Brown-Norway rats having a HK deficiency with Lewis rats for five gene...
متن کاملInfluenza Pathogenesis in Genetically Defined Resistant and Susceptible Murine Strains
The murine infection model is a cornerstone for influenza virus research and includes aspects such as disease pathogenesis, immunobiology, and vaccine and antiviral drug development. One compelling feature of the murine model is the availability of inbred mouse strains, each with a unique genetic makeup and potential for variable responses to influenza infection. Using highly controlled infecti...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1978
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.7822139